Aaron Hanukoglu, M.D.
Division of Pediatric Endocrinology
E. Wolfson Medical Center, Holon
Sackler Faculty of Medicine, Tel-Aviv University, Israel

Full text REPRINTS are available below. Scroll down to see the hyperlinks.

98. Hypothermia is an important clue for hypothyroidism in children and adolescents

Hanukoglu A., Abiri S.
Isr Med Assoc J 26:464-465, 2024. Reprint

97. Autosomal dominant, long-standing Dysglycemia in 2 families with unique phenotypic features

Hanukoglu A., Banne E., Lev D., Wainstein J.
Clin Med Insights Endocrinol Diabetes 17:1-9, 2024. Reprint

96. Unilateral Gynecomastia in an Adolescent with Poland Syndrome. A Clue for Diagnosis

Hanukoglu A., Lev D.
Isr Med Assoc J 25:505-506, 2023. Reprint

95. Is the fear from insulin tolerance test in the evaluation of short stature justified?

Hanukoglu A., Weisglass R.
Eur J Pediatr :, 2022. DOI

94. Renin-aldosterone system evaluation over four decades in an extended family with autosomal dominant pseudohypoaldosteronism due to a deletion in the NR3C2 gene

Hanukoglu A., Vargas-Poussou R., Landau Z., Yosovich K., Hureaux M., Zennaro M.C.
J Steroid Biochem Molec Biol 204:105755, 2020. DOI

93. Expression of the epithelial sodium channel (ENaC) in the endometrium – implications for fertility in a patient with pseudohypoaldosteronism

Boggula V.R., Hanukoglu I., Sagiv R., Enuka Y., Hanukoglu A.
J Steroid Biochem Mol Biol 183:137-141, 2018. Reprint

92. Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa

Sharma S., Hanukoglu A., Hanukoglu I.
J Mol Histol 49:195-208, 2018. Reprint

91. In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient

Hanukoglu A., Hanukoglu I.
Clin Endocrinol. 89:240-241, 2018. Reprint

90. Familial Hyperkalemia and Hypertension (FHHt) and KLHL3 Description of a Family with a New Recessive Mutation (S553L) Compared to a Family with a Dominant Mutation, Q309R, with Analysis of Urinary Sodium Chloride Cotransporter

Kliuk-Ben Bassat O, Carmon V, Hanukoglu A, Ganon L, Massalha E, Holtzman EJ, Farfel Z, Mayan H.
Nephron 137:77-84, 2017.

89. Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages

Hanukoglu I., Boggula V.R., Vaknine H., Sharma S., Kleyman T., Hanukoglu A.
Histochem Cell Biol 147:733–748, 2017. Reprint

88. Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases

Hanukoglu I., Hanukoglu A.
Gene 579:95-132, 2016. Reprint

87. Hypercalciuria in familial hyperkalemia and hypertension with KLHL3 mutations

Mayan H, Carmon V, Oleinikov K, London S, Halevy R, Holtzman EJ, Tenenbaum-Rakover Y, Farfel Z, Hanukoglu A.
Nephron 130:59-65, 2015.

86. Trends in the incidence of type 1 diabetes among Jews and Arabs in Israel

Blumenfeld O, Dichtiar R, Shohat T; Israel IDDM Registry Study Group (IIRSG).
Pediatr Diabetes 15:422-7, 2014.

85. Conserved charged residues at the surface and interface of epithelial sodium channel (ENaC) subunits: roles in cell surface expression and Na+ self-inhibition response

Edelheit O., Ben-Shahar R., Dascal N., Hanukoglu A., Hanukoglu I.
FEBS J 281:2097-2111, 2014. Reprint

84. Lingual thyroid

Landau Z, Abiri S, Barzilay T, Hanukoglu A.
J Pediatr Endocrinol Metab. 26:1021-1022, 2013.

83. Association of the M3151 variant in the transient receptor potential vanilloid receptor-1 (TRPV1) gene with type 1 diabetes in an Ashkenazi Jewish population

Sadeh M, Glazer B, Landau Z, Wainstein J, Bezaleli T, Dabby R, Hanukoglu A, Boaz M, Leshinsky-Silver E.
Isr Med Assoc J 15:477-80, 2013.

82. Increase in the incidence of type 1 diabetes in Israeli children following the Second Lebanon War

Zung A, Blumenfeld O, Shehadeh N, Dally Gottfried O, Tenenbaum Rakover Y, Hershkovitz E, Gillis D, Zangen D, Pinhas-Hamiel O, Hanukoglu A, Rachmiel M, Shalitin S.
Pediatr Diabetes 13:326-333, 2012.

81. Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways

Enuka Y., Hanukoglu I., Edelheit O., Vaknine H., Hanukoglu A.
Histochem Cell Biol 137:339-353, 2012. Reprint

80. Teplizumab for treatment of type 1 diabetes (Protege study)

Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, Bode B, Aronoff S, Holland C, Carlin D, King KL, Wilder RL, Pillemer S, Bonvini E, Johnson S, Stein KE, Koenig S, Herold KC, Daifotis AG; Protege Trial Investigators.
Lancet 378:487-497, 2011.

79. Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12

Muhammad E., Leventhal N., Parvari G., Hanukoglu A., Hanukoglu I., Chalifa-Caspi V., Feinstein Y., Weinbrand J., Jacoby H., Manor E., Nagar T., Beck J.C., Sheffield V.C., Hershkovitz E., Parvari R.
Hum Genet 129:397-405, 2011. DOI

78. Laparoscopic sleeve gastrectomy (LSG) in adolescents with morbid obesity

Landau Z, Karplus G, Hanukoglu A, Abiri S, Levy A, Serour F.
Harefuah 150:765-768, 2011.

77. Identification of the roles of conserved charged residues in the extracellular domain of epithelial sodium channel (ENaC) subunit by alanine mutagenesis

Edelheit O., Hanukoglu I., Dascal N., Hanukoglu A.
Am J Physiol Renal Physiol 300:F887-F897, 2011. Reprint

76. Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC

Edelheit O., Hanukoglu I., Shriki Y., Tfilin M., Dascal N., Gillis, D., Hanukoglu A.
J Steroid Biochem Mol Biol 119:84-88, 2010. Reprint

75. Clinical improvement in patients with autosomal recessive pseudohypoaldosteronism and the necessity for salt supplementation

Hanukoglu A., Hanukoglu I.
Clin Exp Nephrol 14:518-519, 2010. Reprint

74. Neonatal hyperthyrotropinemia; population characteristics, diagnosis, management and outcome after cessation of therapy

Zung A., Tenenbaum-Rakover Y., Barkan S., Hanukoglu A., Hershkovitz E., Pinhas-Hamiel O., Bistritzer T., Zadik Z.
Clin Endocrinol (Oxf) 72:264-271, 2010.

73. Clinical and genetic heterogeneity of congenital adrenal hypoplasia due to NR0B1 gene mutations

Landau Z., Hanukoglu A., Sack J., Goldstein N., Weintrob N., Eliakim A., Gillis D., Sagi M., Shomrat R., Kosinovsky E.B., Anikster Y.
Clin Endocrinol (Oxf) 72:448-454, 2010.

72. Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies

Edelheit O., Hanukoglu A., and Hanukoglu I.
BMC Biotechnology 9:61, 2009. Reprint

71. Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes

Hanukoglu A., Edelheit O., Shriki Y., Gizewska M., Dascal N., Hanukoglu I.
J Steroid Biochem Mol Biol 111:268-274, 2008. Reprint

70. Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease

Hanukoglu A., Curiel B., Berkowitz D., Levine A., Sack J., Lorberboym M.
J Pediatr 153:864-866, 2008. Reprint

69. Atopy in children and adolescents with insulin-dependent diabetes mellitus

Gazit V, Tasher D, Hanukoglu A, Landau Z, Ben-Yehuda Y, Somekh E, Dalal I.
Isr Med Assoc J 10:858-861, 2008.

68. Sulfonylurea-responsive diabetes in childhood

Landau Z., Wainstein J., Hanukoglu A., Tuval M., Lavie J., Glaser B.
J Pediatr 150:553-555, 2007.

67. Congenital hyperreninemic hypoaldosteronism in Israel: sequence analysis of CYP11B2 gene

Leshinsky-Silver E., Landau Z., Unlubay S., Bistrizer T., Zung A., Tenenbaum-Rakover Y., Devries L., Lev D., Hanukoglu A.
Horm Res 66:73-78, 2006. Reprint

66. Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multi-system pseudohypoaldosteronism (Review)

Edelheit O., Hanukoglu I., Gizewska M., Kandemir N., Tenenbaum-Rakover Y., Yurdakok M., Zajaczek S., Hanukoglu A.
Clin Endocrinol. 62:547-553, 2005. Reprint

65. Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment

Zung A., Elizur M., Weintrob N., Bistritzer T., Hanukoglu A., Zadik Z., Phillip M., Miller K., Koren I., Brautbar C., Israel S.
Hum Immunol 65:1463-1468, 2004.

64. An outbreak of echovirus 13 meningitis in central Israel

Somekh E., Cesar K., Handsher R., Hanukoglu A., Dalal I., Ballin A., Shohat T.
Epidemiol Infect 130:257-262, 2003.

63. Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study

Hanukoglu A., Mizrachi A., Dalal I., Admoni O., Rakover Y., Bistritzer Z., Levine A., Somekh E., Lehmann D., Tuval M., Boaz M., Golander A.
Diabetes Care 26:1235-1240, 2003. Reprint

62. Novel mutations responsible for autosomal recessive multi-system pseudohypoaldosteronism and sequence variants in Epithelial Sodium Channel (ENaC) alpha, beta and gamma subunit genes

Saxena A., Hanukoglu I., Saxena D., Thompson R. J., Gardiner R.M., and Hanukoglu A.
J Clin Endocrinol Metab 87:3344-3350, 2002. Reprint

61. Amiloride-sensitive epithelial sodium channel (ENaC) subunits are expressed in human and mussel immunocytes

Ottaviani E., Franchini A., Mandrioli M., Saxena A., Hanukoglu A., Hanukoglu I.
Dev Comp Immunol 26:395-402, 2002. Reprint

60. Aldosterone insensitivity syndromes (pseudohypoaldosteronism): from clinic to molecular biology of sodium transport.

Hanukoglu A., Saxena A., and Hanukoglu I.
Pol J Endocrinol 52 (Suppl. 1):27-37, 2001.

59. Growth hormone activates renin-aldosterone system in children with idiopathic short stature and in a pseudohypoaldosteronism patient with a mutation in epithelial sodium channel alpha subunit

Hanukoglu A., Belutserkovsky O., Phillip M.
J Steroid Biochem Mol Biol 77:49-57, 2001. Reprint

58. Relationship of Etiology to Treatment in Congenital Hypothyroidism

Hanukoglu A., Perlman K., Shamis I., Brnjac L., Rovet J and Daneman D.
J Clin Endocrinol Metab 86:186-191, 2001. Reprint

57. Chronic urticaria in children: Expanding the "autoimmune kaleidoscope"

Dalal I., Levin A., Somekh E., Mizrachi A., Hanukoglu A.
Pediatrics 106:1139-1141, 2000. Reprint

56. Aldosterone unresponsiveness (pseudohypoaldosteronism) results from mutations in epithelial sodium channel subunits [conference].

Hanukoglu A., Saxena A., Gardiner R.M., and Hanukoglu I.
Molecular Steroidogenesis (M. Okamoto, Y. Ishimura, H. Nawata, eds.), Universal Academy Press, Tokyo, Japan, pp. :369-370, 2000.

55. The effect of endogenous dehydroepiandrosterone sulphate (DHEAS) on antibody response to Hepatitis B vaccine in neonates

Somekh E., Dagan R., and Hanukoglu A.
Israel Med Assoc J 2:200-203, 2000.

54. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism

Kerem E., Bistritzer T., Hanukoglu A., Hofmann T., Zhou Z., Bennett W., MacLaughlin E., Barker P., Nash M., Quittell L., Boucher R., and Knowles M. R.
N Engl J Med 341:156-162, 1999. Reprint

53. Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit

Saxena A., Hanukoglu I., Strautnieks S.S., Thompson R.J., Gardiner R.M., and Hanukoglu A.
Biochem Biophys Res Commun 252:208-213, 1998. Reprint

52. Pseudohypoaldosteronism due to renal and multisystem resistance to mineralocorticoids respond differently to carbenoxolone

Hanukoglu A., Joy O., Steinitz M., Rosler A., and Hanukoglu I.
J Steroid Biochem Mol Biol 60:105-112, 1997. Reprint

51. Severe pseudohypoaldosteronism in a pair of twins not associated with hydramnios

Bistritzer T., Lahat E., Eshel G., Barr J., Hanukoglu A., and Aladjem M.
Pediatr Nephrol 10:438-441, 1996. Reprint

50. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

Chang S.S., Grunder S., Hanukoglu A., Rosler A., Mathew P.M., Hanukoglu I., Schild L., Lu Y., Shimkets R.A., Nelson-Williams C., Rossier B.C., and Lifton R.P.
Nat Genet 12:248-253, 1996. Reprint

49. Endogenous methemoglobinemia associated with diarrheal disease in infancy

Hanukoglu A., Danon, P.N.
J Pediatr Gastroenter Nutr 23:1-7, 1996.

48. Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping

Strautnieks S. S., Thompson R. J., Hanukoglu A., Dillon M.J., Hanukoglu I., Kuhnle U., Seckl J., Gardiner R. M., and Chung E.
Hum Mol Genet 5:293-299, 1996. Reprint

47. Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis

Chung E., Hanukoglu A., Rees M., Thompson R., Dillon M., Hanukoglu I., Bistritzer T., Kuhnle U., Seckl J., and Gardiner R.M.
J Clin Endocrinol Metab 80:3341-3345, 1995. Reprint

46. Serious complications of routine ritual circumcision in a neonate

Hanukoglu A., Danielli L., Katzir Z., Gorenstein A., Fried D.
Eur J Pediatr 154:314-16, 1995.

45. Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants

Hanukoglu A., Fried D., Nakash I., and Hanukoglu I.
Eur J Endocrinol 133:552-556, 1995. Reprint

44. Infectious mononucleosis-like illness in an infant with acute herpesvirus 6 infection

Hanukoglu A., Somekh E.
Pediatr Infect Dis J 13: 750-751, 1994.

43. Pseudohypoaldosteronism with increased sweat and saliva electrolyte values and frequent lower respiratory tract infections mimicking cystic fibrosis

Hanukoglu A., Bistritzer T., Rakover Y., Mandelberg A.
J Pediatr 125:752-755, 1994.

42. Pseudohypoaldosteronism with increased sweat and saliva electrolyte values and frequent lower respiratory tract infections mimicking cystic fibrosis

Hanukoglu A., Bistritzer T., Rakover Y., and Mandelberg, A.
J Pediatr 125:752-755, 1994. Reprint

41. The effect of carbenoxolone on the peripheral metabolism of cortisol in human patients

Ulick S., Wang J Z., Hanukoglu A., Rosler A.
J Lab Clin Med 122: 673-676, 1993.

40. Cyclic psychosis associated with the menstrual cycle

Stein D., Hanukoglu A., Blank S., Elizur A.
Brit J Psychiat 163: 824-828, 1993.

39. Benign cystic mesothelioma of the peritoneum: The occurrence of an adult entity in a child

Hanukoglu A., Gewurtz G., Zaidel L., Krispin M., Fried D.
Med Ped Oncology 20:169-71, 1992. DOI

38. Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects

Hanukoglu A.
J Clin Endocrinol Metab 73:936-944, 1991. Reprint

37. Does growth hormone influence the severity of phoshopenic rickets?

Bistritzer T., Chalew S.A., Hanukoglu A., Armour K.M., P.Haney, J, Kowarski AA
150:26-29, 1990.

36. Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells

Hanukoglu I., Feuchtwanger R., and Hanukoglu A.
J Biol Chem 265:20602-20608, 1990. Reprint

35. Human pancreatic polypeptide levels in children and young adults

Hanukoglu A., Chalew S., Kowarski A.A.
Hormone Metab Res 22:41-43, 1990.

34. Quantitative monitoring of brain function, vital signs and hormonal response during acute insulin induced hypoglycemia

Chalew S.R., Sakamoto N., McCarter R., Hanukoglu A., Kowarski A.A.
J Clin Monitoring 5:229-235, 1989.

33. Surgically curable hypophosphatemic rickets. Diagnosis and management

Hanukoglu A., Chalew S., Sun C.C., et al.
Clin Pediatr 28:321-325, 1989.

32. Growth hormone deficiency is not associated with impaired vagal cholinergic nervous system activity in children

Hanukoglu A., Chalew S., Kowarski, A.A.
Pediatr Res 24:574-576, 1988.

31. Late-onset hypocalcemia, rickets, and hypoparathyroidism in an infant of a mother with hyperparathyroidism

Hanukoglu A., Chalew S., Kowarski A.A.
J Pediatr 112:751-754, 1988.

30. Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys

Dubey A.K., Hanukoglu A., Hansen B.C., Kowarski A.A.
J Clin Endocrinol Metab 76:1064-1068, 1988.

29. Increased metabolic clearance rate of growth hormone in obesity parallels increased peripheral insulin resistance and hyperinsulinemia.

Hansen B.C., Dubey A.K., Bodkin N.L., Hanukoglu A., Kowarski, A.A.
Proceedings of the 1st European Congress on Obesity :, 1988.

28. The effect of testosterone therapy on spontaneous growth hormone secretion in boys with constitutional delay

Chalew S., Udoff L.C., Hanukoglu A., Bistritzer T., Armour K.M., Kowarski, A.A.
Am J Dis Child 142:1345-1348, 1988.

27. Radiological case of the month: Periappendicular abscess with intraperitoneal gas formation

Hanukoglu A., Gonsalves D., Mizrachi A. et al.
Am J Dis Child 142:889-890, 1988.

26. Fatal aplastic anemia in a child with Down's syndrome

Hanukoglu A., Meytes D., Fried D. et al.
Acta Paediatr Scan 76:539-543, 1987.

25. Pulmonary involvement in mycoplasma pneumoniae infection in families

Hanukoglu A., Shoara H., Fried D., et al.
Infection 14:1-6, 1986.

24. Inheritance of familial primary endocardial fibroelastosis

Hanukoglu A., Fried D., Somekh E.
Clin Pediatr 25:272-275, 1986.

23. Myocarditis after triple immunization

Amsel S.G., Hanukoglu A., Fried D., et al.
Arch Dis Child 61:403-405, 1986.

22. Loss of voice as a sole symptom of subglottic foreign-body aspiration

Hanukoglu A., Segal S., Fried D.
Am J Dis Child 140:973, 1986.

21. Congenital syphilis with negative VDRL test in pregnancy

Ginot N., Hanukoglu A., Fried D.
Harefuah 109:235-237, 1985.

20. Lung abscess caused by Streptococcus pneumoniae type 3. The importance of counterimmunoelectrophoresis in laboratory diagnosis

Hanukoglu A., Gutman R., Fried D., et al.
Infection 12:85-87, 1984.

19. Benign paroxysmal torticollis in infancy

Hanukoglu A., Somekh E., Fried D.
Clin Pediatr 23:272-274, 1984.

18. Methemoglobinemia in infants with enteritis

Hanukoglu A., Bodner D., Fried D.
J Pediatr 102:161-162, 1983. DOI

17. Acute streptococcal interstitial nephritis

Somekh E., Fried D., Hanukoglu A.
Harefuah 105:316-317, 1983.

16. Kawasaki Disease

Somekh E., Fried D., Hanukoglu A.
Harefuah 104:256-258, 1983.

15. Muscle involvement in Schonlein-Henoch syndrome

Somekh E., Fried D., Hanukoglu A.
Arch Dis Child 58:929-930, 1983. Reprint

14. Micrognathia associated with asternia and telangiectatic skin lesion.

Gotlieb A., Hanukoglu A., Fried D., Rosin, N.
Syndrome Ident 8:10-13, 1982.

13. Diagnosis of acute interstitial nephritis: Is a kidney biopsy necessary?

Somekh E., Fried D., Hanukoglu A., Raviv U.
Pediatrics 65:505, 1982.

12. Differential leukocyte count in shigellosis

Fried D., Maytal Y., Hanukoglu A.
Infection 10:13-15, 1982.

11. Intracerebral hemorrhage in a full-term infant

Geva R., Hanukoglu A., Sahar D., Fried D.
Harefuah 102:19-20, 1982.

10. Leukocyte transfusion in severe neonatal varicella

Fried D., Hanukoglu A., Birk O.
Acta Pediatr Scan 71:147-149, 1982.

9. Abetalipoproteinemia - a case report

Romem M., Yaniv I., Hanukoglu A., Fried D., Goodman R.M.
Metabol Pediatric Ophtalmol 5:29-31, 1981.

8. Pneumomediastinum and subcutaneous emphysema following foreign body aspiration

Hanukoglu A., Fried D., Hadas E.
Harefuah 98:262-263, 1980.

7. Diphenylhydantoin induced hypersensitivity reaction with an unusual purpuric skin lesion

Hanukoglu A., Fried D., Gotlieb A.
Eur J Pediatr 134:177-179, 1980.

6. Torsion of spleen in a five and a half months old child.

Gotlieb A., Fried D., Hanukoglu A., Gaizler K., Siderer M.
Israel J Med Sci 15:35-37, 1979.

5. Inheritance of pseudohypoaldosteronism

Hanukoglu A., Fried D., and Gotlieb A.
Lancet 1:1359-1359, 1978. Reprint

4. An unusual course of mumps meningoencephalitis

Hanukoglu A., Fried D., Gotlieb A.
Harefuah 95:26-27, 1978.

3. Glucose and insulin responses to an oral glucose load in normal children and adolescents in Israel

Josefsberg Z., Vilunski E., Hanukoglu A., Bialik O., Brown M., and Laron Z.
Israel J Med Sci 12:189-194, 1976.

2. Fetal transfusion syndrome

Fried D., and Hanukoglu A.
British Med J 2:526, 1976.

1. Anaphylactic shock due to tetanus toxoid

Hanukoglu A., Fried D., and Gotlieb A.
Harefuah 89:456-457, 1975.